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Second Life Therapeutics

Meet SLT
Redefining Cancer
Treatment

At Second Life Therapeutics, we are reshaping how difficult-to-treat and refractory solid tumors are approached, including cancers once considered “untreatable”

Our Breakthrough Therapy: SL‑28

We are a clinical-stage biopharmaceutical company advancing Leukocyte-Tells (SL‑28), the first-in-class, allogeneic, non-genetically modified adoptive cell therapy. SL‑28 therapy is tumor-agnostic, highly active against solid tumors, ready-to-use, and based on a New Biology concept overcoming the limitations of current approaches.

The Science Behind SL‑28

Our scientists and medical team discovered the Universal Receptive System and its unique Teazeled receptors (TezRs) through which, for the first time, we can modulate cellular memory. We transform donor-derived immune cells into Leukocyte-Tells (SL‑28) that are capable of targeting a broad spectrum of solid tumors with unprecedented levels of response. Our science has unlocked anticancer mechanisms that were previously unknown.

Why SL-28

  • Cancer-agnostic

    01

    Designed to address multiple tumor types resistant to current therapies.

  • Ready-to-use

    02

    immediate access for patients, avoiding the long delays of custom manufacturing typical for other cell-therapies.

  • Refractory solid tumors

    03

    SL-28 works on “untreatable” and treatment-refractory solid tumors, and uses several novel anticancer mechanisms that were recently discovered by our team of scientists.

Who we are

Second Life Therapeutics is part of Second Life Group, a collective of biotech companies addressing medicine's most critical, unmet needs, with science and technology developed in close collaboration with Tetz Laboratories in New York. Together, we are pioneering a new generation of therapies that bring hope to patients facing the most challenging cancers.

Second Life Group
At Second Life Therapeutics,
Therapeutics,
we treat the most advanced
most advanced
and refractory tumors, providing
tumors, providing
a second chance at
chance at
life for patients in need
in need
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Founders
scientific

Second Life Therapeutics is led by an accomplished team of physicians and scientists with extensive experience in biotechnology and drug development who consider their science as a form of art.

Professor

Victor Tetz

MD
PhD
Co-Founder, Chief Scientific Officer

George Tetz

MD
PhD
Co-Founder, Chief Scientific Officer

New York

Second Life Therapeutics is a global company with scientific sites on two continents in the United States and Australia, aimed to bring the innovation of the Universal Receptive System to those in need.

USA, New York, 101 Avenue of the Americas
3rd Floor, NY 10013
+1 844 844 0162
Corporate headquarters

California

Manufacturing

Second Life Therapeutics partners with leading manufacturing experts to ensure that Leukocyte-Tells (SL-28) reach patients rapidly, reliably, and at the highest quality.

Safety and Quality

Working hand in hand with the manufacturing facility, Second Life Therapeutics team oversees every stage of clinical-grade production and quality control. This guarantees consistency, safety, and reproducibility across all batches.

Supporting Patients and Trials

With the integrated approach, we deliver a dependable supply of SL-28 to power our clinical development programs and to patients receiving treatment through expanded access pathway.

Australia

Australia, Second LIfe Therapeutics
L2 169 Pirie ST, Adelaide SA 5000
+61 39 245 1001
Clinical development

VictorTetz

Victor Tetz, M.D., Ph.D., is cofounder and chief scientific officer at Second Life Therapeutics.

Throughout his career, Dr. Victor Tetz made multiple breakthrough discoveries related to microbiology and cell regulation further developed by NASA, P&G, Dole, PepsiCo, and others. Prior to joining Second Life Therapeutics, Dr. Victor Tetz was a professor of microbiology and spent over four decades in academia. His research centered on host reactions to cell regulation, microbiome, and microbial virulence.

Dr. Victor Tetz was the first to determine the number of RNA genome fragments in the influenza virus, discover previously unknown bacterial species, and demonstrate the biological importance of minor DNA components in cellular processes.

He pioneered the study of multicellular behavior in bacteria, being the first to describe the structure and composition of the microbial biofilm surface layer and to develop early methods for targeting the biofilm matrix as a new approach to antimicrobial therapy.

Among his most groundbreaking discoveries is the identification of the previously unknown Universal Receptive System and TezR receptors. He also uncovered novel mechanisms regulating cell memory, paving the way for the development of next-generation therapeutic modalities.
With this discovery, Dr. Tetz is modulating cellular memory for the first time, bringing cell control to a new and unprecedented level.

He serves as Head of the Human Microbiology Institute, where he plays an integral role in numerous breakthrough discoveries.

GeorgeTetz

George Tetz, M.D., Ph.D., joined Second Life Therapeutics in June 2023 as Chief Executive Officer and Board Member.

As a renowned figure in the New York biotech industry, Dr. George Tetz has dedicated his life’s work to addressing some of medicine’s most critical unmet needs.  Throughout his career as both a medical practitioner and researcher, Dr. Tetz has focused on applying cutting-edge multifactorial approaches to a variety of medical problems. He discovered previously unknown bacteria that cause human diseases and developed the first methods to target the microbial biofilm matrix as a novel therapeutic approach to antimicrobial therapy.

One of his most groundbreaking findings is the existence of the previously unknown Universal Receptive System and Teazeled receptors. With this discovery, Dr. Tetz is modulating cellular memory for the first time, bringing cell control to a new and unprecedented level.

Second Life Therapeutics is led by an accomplished team of physicians and scientists with extensive experience in biotechnology and drug development who consider their science as a form of art.

Articles
June 9, 2026

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press@secondlifegrp.com

Articles
June 9, 2026
Articles
May 19, 2026

Second Life Therapeutics Presents SL-28 Complete Response Case Report at the American Thoracic Society 2026 International Conference

Novel off-the-shelf cell therapy SL-28 was associated with complete response in a patient with malignant pleural effusion under compassionate use. Data from a stage IV non-small cell lung cancer patient with malignant pleural effusion were presented at ATS 2026, one of the world’s largest respiratory medicine conferences, held May 15–20, 2026, in Orlando, Florida.

New York, NY, May 19, 2026. Second Life Therapeutics announced the publication of a case report abstract in the American Journal of Respiratory and Critical Care Medicine supplement describing a complete response in a patient with stage IV non-small cell lung cancer and malignant pleural effusion treated with SL-28, the company’s investigational allogeneic cell therapy.

The clinical case report, titled “Complete Response in a Patient With Non-Small Cell Lung Cancer and Malignant Pleural Effusion to a Novel Cell Therapy SL-28: A Case Report,” describes the treatment of an 82-year-old male patient with advanced lung cancer and persistent malignant pleural effusion who showed no tumor response after two cycles of chemotherapy.

SL-28, also known as Leukocyte-Tells, is a novel cell therapy based on allogeneic leukocytes whose anticancer activity is altered ex vivo through TezR receptors, without direct genetic modification. According to the abstract, Leukocyte-Tells are characterized by upregulated pathways associated with immune cell migration, signaling, and enhanced energy metabolism, and have demonstrated activity against multiple types of solid tumors.

The patient received SL-28 under compassionate use. Treatment was well tolerated, with no graft-versus-host disease, cytokine release syndrome, or immune effector cell-associated neurotoxicity syndrome observed.

After three weeks of SL-28 therapy, CT imaging demonstrated stable disease according to RECIST 1.1, including no growth of the S6 lesions and an approximately 80% reduction of the S3 lesion. By week eight, CT imaging showed a partial response, including complete resolution of one S6 lesion and the S3 lesion, along with a marked reduction in pleural fluid volume.

By week 22, no new nodules were observed, all S6 lesions had disappeared, and the remaining tumor in S3 was no longer visible. Fine-needle biopsy performed at the original lesion site showed no malignant cells and only fibrotic tissue. Together with CT imaging, these findings were consistent with a complete response under RECIST 1.1. The patient was monitored for an additional six months after completing SL-28 therapy, with no evidence of disease recurrence.

“This case report represents an important clinical observation for SL-28 in advanced solid tumors,” said George Tetz, MD, PhD, founder of Second Life Therapeutics and co-author of the abstract. “The complete response observed in a patient with stage IV non-small cell lung cancer and malignant pleural effusion supports further clinical evaluation of SL-28 as a potential off-the-shelf cell therapy for advanced malignancies.”

The abstract concludes that SL-28 demonstrated safety and clinical activity in this patient with stage IV lung cancer and supports its continued development for advanced malignancies.

About SL-28

SL-28, also known as Leukocyte-Tells, is an investigational allogeneic, non-genetically modified cell therapy developed by Second Life Therapeutics. SL-28 uses donor-derived leukocytes whose anticancer activity is modulated ex vivo through TezR receptors to enhance immune cell function, including migration, signaling, and energy metabolism.

About Second Life Therapeutics

Second Life Therapeutics is a biotechnology company developing novel cell-based therapies for advanced malignancies and other serious diseases. The company’s lead investigational therapy, SL-28, is being developed as an off-the-shelf cellular therapy for solid tumors.

Forward-Looking Statement

SL-28 is an investigational therapy and has not been approved by the U.S. Food and Drug Administration or other regulatory authorities. This press release includes findings from a single-patient case report under compassionate use. Additional clinical studies are required to evaluate the safety and efficacy of SL-28.

Media Contact

press@secondlifegrp.com

Articles
May 19, 2026